Models,Multiomics

Dataset Information

0

Smallbone2013 - Human metabolism global reconstruction (recon 2.1x)


ABSTRACT: Smallbone2013 - Human metabolism global reconstruction (recon 2.1x) Recon 2.1x. This model is described in the article: Striking a balance with Recon 2.1 Kieran Smallbone Molecular Networks (q-bio.MN) Abstract: Recon 2 is a highly curated reconstruction of the human metabolic network. Whilst the network is state of the art, it has shortcomings, including the presence of unbalanced reactions involving generic metabolites. By replacing these generic molecules with each of their specific instances, we can ensure full elemental balancing, in turn allowing constraint-based analyses to be performed. The resultant model, called Recon 2.1, is an order of magnitude larger than the original. This model is hosted on BioModels Database and identified by: MODEL1311110001 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Kieran Smallbone  

PROVIDER: MODEL1311110001 | BioModels | 2005-01-01

REPOSITORIES: BioModels

altmetric image

Publications

Metabolism of vitamin D3 by cytochromes P450.

Sakaki Toshiyuki T   Kagawa Norio N   Yamamoto Keiko K   Inouye Kuniyo K  

Frontiers in bioscience : a journal and virtual library 20050101


The vitamin D3 25-hydroxylase (CYP27A1), 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) and 1alpha,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) are members of the cytochrome P450 superfamily, and key enzymes of vitamin D3 metabolism. Using the heterologous expression in E. coli, enzymatic properties of the P450s were recently investigated in detail. Upon analyses of the metabolites of vitamin D3 by the reconstituted system, CYP27A1 surprisingly produced at least seven forms of minor metabo  ...[more]

Publication: 1/2787

Similar Datasets

2005-01-01 | MODEL1311110000 | BioModels
2005-01-01 | MODEL1109130000 | BioModels
2022-05-16 | MODEL2205110002 | BioModels
| S-EPMC4896983 | biostudies-literature
2016-11-28 | GSE75667 | GEO
2014-03-26 | E-MTAB-2427 | biostudies-arrayexpress
| S-EPMC3945653 | biostudies-literature
2024-04-30 | GSE244176 | GEO
2024-04-30 | GSE244125 | GEO
2014-12-18 | E-GEOD-58707 | biostudies-arrayexpress