Genotyping of human morphologically challenging cases of renal epithelial neoplasms by virtual karyotypes

ABSTRACT: Renal tumors with complex morphology require extensive workup for accurate classification. Chromosomal aberrations that define subtypes of renal epithelial neoplasms have been reported. We explored if whole-genome chromosome copy number and loss-of-heterozygosity analysis with single nucleotide polymorphism (SNP) arrays can be used to identify these aberrations in cases where morphology was unable to definitively classify these tumors. Experiment Overall Design: We analyzed 50 paraffin-embedded tissues representing tumors with classic morphology from clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, and oncocytoma with Affymetrix GeneChip 10K 2.0 Mapping arrays. We then analyzed 25 tumors that could not be classified by morphology and classified them based on the pr

ORGANISM(S): Homo sapiens

SUBMITTER: Federico Monzon 

PROVIDER: E-GEOD-11447 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress