Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Marek Bartkuhn
PROVIDER: E-GEOD-12749 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bartkuhn Marek M Straub Tobias T Herold Martin M Herrmann Mareike M Rathke Christina C Saumweber Harald H Gilfillan Gregor D GD Becker Peter B PB Renkawitz Rainer R
The EMBO journal 20090219 7
For the compact Drosophila genome, several factors mediating insulator function, such as su(Hw) and dCTCF, have been identified. Recent analyses showed that both these insulator-binding factors are functionally dependent on the same cofactor, CP190. Here we analysed genome-wide binding of CP190 and dCTCF. CP190 binding was detected at CTCF, su(Hw) and GAF sites and unexpectedly at the transcriptional start sites of actively transcribed genes. Both insulator and transcription start site CP190-bin ...[more]