Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of genome-wide binding of the insulator factors CTCF and CP190


ABSTRACT: We identified about 3000 CTCF sites in the genome. In addition to binding to CTCF sites we found CP190 to bind to transcriptional start sites of actively transcribed genes where it inversely correlates with nucleosome occupancy. Keywords: ChIP-chip CTCF and CP190 ChIP. 2 biological replicates per experiment. dye-swaps as indicated in sample description.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Marek Bartkuhn 

PROVIDER: E-GEOD-12749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Active promoters and insulators are marked by the centrosomal protein 190.

Bartkuhn Marek M   Straub Tobias T   Herold Martin M   Herrmann Mareike M   Rathke Christina C   Saumweber Harald H   Gilfillan Gregor D GD   Becker Peter B PB   Renkawitz Rainer R  

The EMBO journal 20090219 7


For the compact Drosophila genome, several factors mediating insulator function, such as su(Hw) and dCTCF, have been identified. Recent analyses showed that both these insulator-binding factors are functionally dependent on the same cofactor, CP190. Here we analysed genome-wide binding of CP190 and dCTCF. CP190 binding was detected at CTCF, su(Hw) and GAF sites and unexpectedly at the transcriptional start sites of actively transcribed genes. Both insulator and transcription start site CP190-bin  ...[more]

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