Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Motohiro Kato
PROVIDER: E-GEOD-12906 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kato Motohiro M Sanada Masashi M Kato Itaru I Sato Yasuharu Y Takita Junko J Takeuchi Kengo K Niwa Akira A Chen Yuyan Y Nakazaki Kumi K Nomoto Junko J Asakura Yoshitaka Y Muto Satsuki S Tamura Azusa A Iio Mitsuru M Akatsuka Yoshiki Y Hayashi Yasuhide Y Mori Hiraku H Igarashi Takashi T Kurokawa Mineo M Chiba Shigeru S Mori Shigeo S Ishikawa Yuichi Y Okamoto Koji K Tobinai Kensei K Nakagama Hitoshi H Nakahata Tatsutoshi T Yoshino Tadashi T Kobayashi Yukio Y Ogawa Seishi S
Nature 20090503 7247
A20 is a negative regulator of the NF-kappaB pathway and was initially identified as being rapidly induced after tumour-necrosis factor-alpha stimulation. It has a pivotal role in regulation of the immune response and prevents excessive activation of NF-kappaB in response to a variety of external stimuli; recent genetic studies have disclosed putative associations of polymorphic A20 (also called TNFAIP3) alleles with autoimmune disease risk. However, the involvement of A20 in the development of ...[more]