Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse extraocular and hindlimb muscle to determine gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56


ABSTRACT: Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain.

ORGANISM(S): Mus musculus

SUBMITTER: Henry Kaminski 

PROVIDER: E-GEOD-1472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice.

Porter John D JD   Khanna Sangeeta S   Kaminski Henry J HJ   Rao J Sunil JS   Merriam Anita P AP   Richmonds Chelliah R CR   Leahy Patrick P   Li Jingjin J   Guo Wei W   Andrade Francisco H FH  

Human molecular genetics 20020201 3


Mutations in dystrophin cause Duchenne muscular dystrophy (DMD), but absent dystrophin does not invariably cause necrosis in all muscles, life stages and species. Using DNA microarray, we established a molecular signature of dystrophinopathy in the mdx mouse, with evidence that secondary mechanisms are key contributors to pathogenesis. We used variability controls, adequate replicates and stringent analytic tools, including significance analysis of microarrays to estimate and manage false positi  ...[more]

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