Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression analysis of Streptomyces avermitilis NRRL8165 delta-aveI mutant

ABSTRACT: Investigation of whole genome gene expression level changes in Streptomyces avermitilis delta-aveI mutant, compared to the wild-type strain. The mutants analyzed in this study are further described in Chen L, Lu Y., Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. (2008) Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl Microbiol Biotechnol 80(2): 277-86. A six chip study using total RNA recovered from three separate Streptomyces avermitilis NRRL8165 and three separate cultures of a Streptomyces avermitilis NRRL8165 delta-aveI (delta-l) mutant. 3 separate RMA normalizations performed, one for each pair of control and mutant samples.

ORGANISM(S): Streptomyces avermitilis

SUBMITTER: Jun Chen 

PROVIDER: E-GEOD-16892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis.

Chen Lei L   Chen Jun J   Jiang Yuqian Y   Zhang Weiwen W   Jiang Weihong W   Lu Yinhua Y  

FEMS microbiology letters 20090710 2

In our previous studies, AveI was identified as a negative regulator for avermectin biosynthesis in Streptomyces avermitilis NRRL8165, and the aveI-null mutant of NRRL8165 could produce at least 10-fold more avermectin B1a than its wild-type strain. In order to explore the regulatory mechanism by which aveI affects avermectin biosynthesis, in this study, we performed a global comparative gene expression analysis between aveI deletion mutant 8165DeltaI and its wild-type strain using NimbleGen mic  ...[more]

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