Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Julie Claycomb
PROVIDER: E-GEOD-18165 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Claycomb Julie M JM Batista Pedro J PJ Pang Ka Ming KM Gu Weifeng W Vasale Jessica J JJ van Wolfswinkel Josien C JC Chaves Daniel A DA Shirayama Masaki M Mitani Shohei S Ketting René F RF Conte Darryl D Mello Craig C CC
Cell 20091001 1
RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3, and the Tudor-domain protein EKL-1 localize to chromosomes and are required for proper chromosome segregation. In the absence of these factors chromosomes fail to align at the metaphase plate and kinetochores do not orient to opposing spindle poles. Surprisingly, the CSR ...[more]