Comparison of post-mortem tissue from Brodman Brain BA22 region between schizophrenic and control patients

ABSTRACT: Transcriptional analysis of the superior temporal cortex (BA22) in schizophrenia: Pathway insight into disease pathology and drug development Schizophrenia is a highly debilitating psychiatric disorder which is known to have heritable genetic and environmental components. To gain some insight into the mechanisms underpinning both positive and negative symptoms of the disease, we determined the genome wide expression of mRNA transcripts in post-mortem tissue from the superior temporal cortex (Brodmann Area 22, BA22) in schizophrenic and control patients. The BA22 region is known to mediate the positive pathophysiology of schizophrenia; we compared this to the anterior prefrontal cortex (BA10) from the same subjects, which is known to mediate negative symptoms. Following adjustments for conf

ORGANISM(S): Homo sapiens

SUBMITTER: Julie Huxley-Jones 

PROVIDER: E-GEOD-21935 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress