Aspergillus fumigatus HapX-mediated iron starvation adaption is required for virulence.

ABSTRACT: Iron is an essential cofactor for a wide range of cellular processes. Previous studies have shown that siderophore-mediated uptake and intracellular handling of iron are crucial for virulence of Aspergillus fumigatus. Here we show that the bzip-type transcription factor HapX plays a crucial role in the transcriptional remodeling required for adaption to iron starvation in this opportunistic fungal pathogen. HapX was found to be interconnected in a negative feed-back loop with the previously identified iron regulator SreA: SreA repressed expression of hapX during iron sufficiency and HapX repressed sreA during iron starvation. Genome-wide transcriptional profiling and analysis of selected metabolites (protophorphyrine IX, siderophores and amino acids) indicated extensive metabolic remodelin

ORGANISM(S): Aspergillus fumigatus

SUBMITTER: John Varga 

PROVIDER: E-GEOD-22052 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress