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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Zebularine effect on mouse embryonic stem cells manifested as cardiod-myogenic potential: testable hypothesis generation using microarray data

ABSTRACT: Lineage commitment during Embryonic Stem Cells (ESCs) differentiation is controlled not only by a gamut of transcription factors but also by epigenetic events, mainly histone deacetylation and promoter DNA methylation. Moreover, the DNA demethylation agent 5′-Aza-2′-deoxycytidine (AzadC) has been widely described in the literature as an effective chemical stimulus used to promote cardiomyogenic differentiation in various stem cell types; however, its toxicity and instability complicate its use. Thus, the purpose of this study was to examine the effects of zebularine, a stable and non-toxic DNA cytosine methylation inhibitor, on ESCs differentiation. Herein are the Affymetrix Expression data obtained from RNA of murine ESCs treated with zebularine. 9 control samples (replicates) and 9 zebularine samples (replicates).

ORGANISM(S): Mus musculus

SUBMITTER: karim hmadcha

PROVIDER: E-GEOD-29072 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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