Unknown,Transcriptomics,Genomics,Proteomics

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Affymetrix SNP array data for hepatocellular carcinoma tissue


ABSTRACT: Genetic variations play an important role in tumor development and metastasis. Hepatocellular carcinoma (HCC) is one of leading cause of cancer-related death. Despite improvements in surveillance and clinical treatment strategies, the prognosis of HCC remains dismal. Affymetrix SNP 6.0 array were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients who were underwent liver transplantation. Recurrence related SNPs were selected and validated. Affymetrix SNP 6.0 arrays were performed according to the manufacturer's directions on DNA extracted from formalin-fixed paraffin-embedded HCC tissues

ORGANISM(S): Homo sapiens

SUBMITTER: jie hu 

PROVIDER: E-GEOD-29667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation.

Hu Jie J   Wang Zheng Z   Fan Jia J   Dai Zhi Z   He Yi-Feng YF   Qiu Shuang-Jian SJ   Huang Xiao-Wu XW   Sun Jian J   Xiao Yong-Sheng YS   Song Kang K   Shi Ying-Hong YH   Sun Qi-Man QM   Yang Xin-Rong XR   Shi Guo-Ming GM   Yu Lei L   Yang Guo-Huan GH   Ding Zhen-Bin ZB   Gao Qiang Q   Tang Zhao-You ZY   Zhou Jian J  

PloS one 20111005 10


<h4>Background</h4>Recurrence prediction of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) present a great challenge because of a lack of biomarkers. Genetic variations play an important role in tumor development and metastasis.<h4>Methods</h4>Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorphis  ...[more]

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