Unknown,Transcriptomics,Genomics,Proteomics

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Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE29704: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data] GSE29705: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data] Refer to individual Series

ORGANISM(S): Halobacterium sp. NRC-1

SUBMITTER: Amy Schmid 

PROVIDER: E-GEOD-29706 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability.

Schmid Amy K AK   Reiss David J DJ   Pan Min M   Koide Tie T   Baliga Nitin S NS  

Molecular systems biology 20090616


During evolution, enzyme-coding genes are acquired and/or replaced through lateral gene transfer and compiled into metabolic pathways. Gene regulatory networks evolve to fine tune biochemical fluxes through such metabolic pathways, enabling organisms to acclimate to nutrient fluctuations in a competitive environment. Here, we demonstrate that a single TrmB family transcription factor in Halobacterium salinarum NRC-1 globally coordinates functionally linked enzymes of diverse phylogeny in respons  ...[more]

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