Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Isolation and in vitro expansion of human colonic stem cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE31255: Isolation and in vitro expansion of human colonic stem cells [Expression profile] GSE31256: Isolation and in vitro expansion of human colonic stem cells [CGH] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Eduard Batlle 

PROVIDER: E-GEOD-31257 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Here we describe the isolation of stem cells of the human colonic epithelium. Differential cell surface abundance of ephrin type-B receptor 2 (EPHB2) allows the purification of different cell types from human colon mucosa biopsies. The highest EPHB2 surface levels correspond to epithelial colonic cells with the longest telomeres and elevated expression of intestinal stem cell (ISC) marker genes. Moreover, using culturing conditions that recreate the ISC niche, a substantial proportion of EPHB2-h  ...[more]

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