Progression of Neuroblastoma Tumor

ABSTRACT: Previous studies have reported that metastatic tumor cells acquire genomic aberrations compared to those present in the primary due to an unstable genome. However, it is not clear if all malignancies follow a similar pattern. Neuroblastoma is the most common extra-cranial solid tumor of childhood. To examine how the neuroblastoma genome changes during tumor progression, we investigated chromosomal structural alterations across three tumors from a patient with hisg-risk neuroblastoma. The tumors included the primary tumor, one metastatis collected at diagnosis before any treatment, and a second metastatis collected during post mortem investigation. The recapitulated chromosomal structural alterations demonstrated that all three tumors had extensive chromosomal alterations involving virtuall

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Johansson 

PROVIDER: E-GEOD-33987 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress