Transciptome analysis of Salmonella enterica serovar Typhimurium UK1 delta-rsiM at oxidative stress
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ABSTRACT: Salmonella has various mechanisms of small RNA-mediated gene regulation. In Salmonella enterica serovar Typhimurium, a novel intergenic transcript RsiM is involved in oxidative stress response which functions as one of the powerful antimicrobials in macrophage innate immunity. We note that the M-bM-^HM-^FrsiM mutant is sensitive to hydrogen peroxide (5.0mM). This finding provides insights into the function of RsiM as a regulator of oxidative stress response. UK1 wild-type and M-bM-^HM-^FrsiM strains were grown in LB medium at 37M-bM-^DM-^C to an OD600 of 0.6, and then subjected to oxidative stress (5.0 mM hydroperoxide) for 30 min. Total RNA was extracted from three biological replicates of wild-type and M-bM-^HM-^FrsiM mutant.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1
SUBMITTER: Yong Keun Park
PROVIDER: E-GEOD-37626 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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