Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ben Wittner
PROVIDER: E-GEOD-40174 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yu Min M Ting David T DT Stott Shannon L SL Wittner Ben S BS Ozsolak Fatih F Paul Suchismita S Ciciliano Jordan C JC Smas Malgorzata E ME Winokur Daniel D Gilman Anna J AJ Ulman Matthew J MJ Xega Kristina K Contino Gianmarco G Alagesan Brinda B Brannigan Brian W BW Milos Patrice M PM Ryan David P DP Sequist Lecia V LV Bardeesy Nabeel N Ramaswamy Sridhar S Toner Mehmet M Maheswaran Shyamala S Haber Daniel A DA
Nature 20120701 7408
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. Although these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic device for efficient capture of CTCs from an endogenous mouse pancreatic cancer model and subjected CTCs to single-molecule RNA sequencing, identifying Wnt2 as a candidate gene enriched in CTCs. Exp ...[more]