Unknown,Transcriptomics,Genomics,Proteomics

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The Hematopoietic System - Myeloid arm


ABSTRACT: We used microarray to create a normal cell landscape for the myeloid arm of the hematopoietic system. Mononuclear bone marrow cells from heathly donors were enriched for 34+ and hematopoietic stem and progenitor cells were sorted by FACS.

ORGANISM(S): Homo sapiens

SUBMITTER: Nicolas Rapin 

PROVIDER: E-GEOD-42519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.

Rapin Nicolas N   Bagger Frederik Otzen FO   Jendholm Johan J   Mora-Jensen Helena H   Krogh Anders A   Kohlmann Alexander A   Thiede Christian C   Borregaard Niels N   Bullinger Lars L   Winther Ole O   Theilgaard-Mönch Kim K   Porse Bo T BT  

Blood 20131220 6


Gene expression profiling has been used extensively to characterize cancer, identify novel subtypes, and improve patient stratification. However, it has largely failed to identify transcriptional programs that differ between cancer and corresponding normal cells and has not been efficient in identifying expression changes fundamental to disease etiology. Here we present a method that facilitates the comparison of any cancer sample to its nearest normal cellular counterpart, using acute myeloid l  ...[more]

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