Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression in mouse primary pre-B cells transduced with Ikaros


ABSTRACT: Ikaros family DNA binding proteins are critical regulators of B cell development. To identify Ikaros-regulated genes in primary pre-B cells we performed gene expression microarrays. We used retroviral gene transfer to express Ikaros proteins. Total RNA from 3 biological replicates of primary pre-B cells transduced with wild type Ikaros (HA-Ikaros-IRES-GFP) and control vector (IRES-GFP) was isolated 48h after infection.

ORGANISM(S): Mus musculus

SUBMITTER: Gopuraja Dharmalingam 

PROVIDER: E-GEOD-42551 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ikaros family DNA-binding proteins are critical regulators of B-cell development. Because the current knowledge of Ikaros targets in B-cell progenitors is limited, we have identified genes that are bound and regulated by Ikaros in pre-B cells. To elucidate the role of Ikaros in B-cell lineage specification and differentiation, we analyzed the differential expression of Ikaros targets during the progression of multipotent to lymphoid-restricted progenitors, B- and T-cell lineage specification, an  ...[more]

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