Classifying distinct grades of human non-alcoholic fatty liver disease employing a systems biology approach

ABSTRACT: With an estimated prevalence of about 30% in western countries non-alcoholic fatty liver disease (NAFLD) is a major public health issue [PMID: 18956290]. NAFLD is associated with the metabolic syndrome of insulin resistance, obesity, glucose intolerance. Although many studies are pointing to an induction of insulin resistance by NAFLD causality between both phenotypes is not fully clarified. Furthermore, mechanisms leading to strongly differing progression of NAFLD have to be elucidated which range from mild steatosis up to severe steatohepatitis. Steatohepatitis might even result in liver cirrhosis and hepatocellular carcinoma. Additional complexity is introduced into the understanding of the disease by recent studies providing evidence for a direct development of carcinoma from steatosis

ORGANISM(S): Homo sapiens

SUBMITTER: Wasco Wruck 

PROVIDER: E-GEOD-46300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress