Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Suling Liu
PROVIDER: E-GEOD-59361 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20140912 22
miRNAs are essential for self-renewal and differentiation of normal and malignant stem cells by regulating the expression of key stem cell regulatory genes. Here, we report evidence implicating the miR100 in self-renewal of cancer stem-like cells (CSC). We found that miR100 expression levels relate to the cellular differentiation state, with lowest expression in cells displaying stem cell markers. Utilizing a tetracycline-inducible lentivirus to elevate expression of miR100 in human cells, we fo ...[more]