Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

MiRNA expression in healthy carriers of heterozygous BRCA1 mutation and healthy WT controls


ABSTRACT: In order to investigate whether carriers of BRCA1 heterozygous mutation show altered miRNA expression profiles, we established a panel of lymphoblastoid cell lines (LCLs) harboring either mutated or WT BRCA1 (control) and investigated their miRNA expression profiles. We were especially interested whether we find differences in miRNA expression between carriers of missense versus truncating mutation in BRCA1 gene. We evaluated the miRNA expression in a panel of 21 non-treated lymphoblastoid cell lines (LCLs). Among them, 6 LCLs with WT BRCA1, 5 LCLs carrying missense mutation in BRCA1, and 10 LCLs harboring truncating mutation in BRCA1 were included in this study.

ORGANISM(S): Homo sapiens

SUBMITTER: Tereza Vaclova 

PROVIDER: E-GEOD-60444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-12-31 | E-GEOD-60396 | biostudies-arrayexpress
2015-12-31 | GSE60444 | GEO
2015-12-31 | GSE60396 | GEO
2008-03-21 | GSE10905 | GEO
2010-01-20 | GSE17764 | GEO
2021-06-15 | MSV000087622 | MassIVE
2008-11-19 | E-GEOD-13671 | biostudies-arrayexpress
2008-11-20 | GSE13671 | GEO
2013-01-10 | E-GEOD-39976 | biostudies-arrayexpress
2011-04-28 | E-GEOD-28044 | biostudies-arrayexpress