IL-27 stimulation in Foxp3+ Tregs improves suppressive function and therapeutic efficacy

ABSTRACT: Foxp3 expressing regulatory T cells (Tregs) are the central regulator of immune homeostasis and tolerance. As it is believed that proper Treg function is compromised under inflammatory conditions, exploring a pathway that enhances Treg function is of great importance. In this study, we report that IL-27, an IL-12 family cytokine known to play both pro- and anti-inflammatory role in T cells, plays a pivotal role in Treg function to control T cell-induced colitis. Unlike WT Tregs capable of inhibiting colitogenic T cell expansion and inflammatory cytokine expression, IL-27R-deficient Tregs were unable to downregulate inflammatory T cell responses. Tregs stimulated with IL-27 expressed substantially enhanced suppressive function both in vitro and in vivo. IL-27 stimulation of Tregs induced ex

ORGANISM(S): Mus musculus

SUBMITTER: Yibayiri Sanogo 

PROVIDER: E-GEOD-63455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress