Different exercise modalities have distinct effects on the transcriptome profile in the male rat femoral diaphysis

ABSTRACT: Mechanical loading is a key determinant of bone mass, geometry and strength and is essential to maintain optimal skeletal health. We hypothesized that spontaneous low-impact exercise would affect global gene transcript levels in cortical bone of growing rats. We used RNA-Seq to analyse the transcriptome of the femoral mid-diaphysis in pre-pubertal male rats that were assigned to one of three exercise groups for 15 days: control (CON); bipedal stance (BPS); and wheel exercise (WEX). RNA-seq analysis identified 808 and 324 differentially expressed transcripts in the BPS and WEX animals, respectively. In WEX animals, the up-regulated transcripts were enriched for gene ontology terms associated with bone metabolism. Both BPS and WEX animals showed changes in transcripts that were enriched for

ORGANISM(S): Rattus norvegicus

SUBMITTER: Justin O'Sullivan 

PROVIDER: E-GEOD-67787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress