Transcription profiling of mouse naive and tolerant macrophages stimulated with LPS

ABSTRACT: The inflammatory response initiated by microbial products signaling through Toll-like receptors (TLRs) of the innate immune system is essential for host defense against infection. Because inflammation can be harmful to host tissues, the innate response is highly regulated. Negative regulation of TLR4, the receptor for bacterial lipopolysaccharide (LPS), results in LPS tolerance, defined as hyporesponsiveness to repeated stimulation with LPS. LPS tolerance is thought to protect the host from excessive inflammation by turning off TLR4 signal, which then shuts down TLR-induced genes. However, TLR signaling induces hundreds of genes with very different functions. We reasoned that genes with different functions should have different requirements for regulation. Specifically, genes encoding p

ORGANISM(S): Mus musculus

SUBMITTER: Simmie Foster 

PROVIDER: E-GEOD-7348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress