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MiRNA expression profile of PBMCs in healthy subjects after extra virgin olive oil (EVOO) intake - Part 2 (Controls)

ABSTRACT: miRNA expression profiles of PBMCs in healthy subjects following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of PBMCs after EVOO intake. Results provide the information of changes in PBMPs transcriptome following EVOO intake. RNA obtained from PBMCs of the same patients before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples) - Controls

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Moschetta 

PROVIDER: E-GEOD-75026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil.

D'Amore Simona S   Vacca Michele M   Cariello Marica M   Graziano Giusi G   D'Orazio Andria A   Salvia Roberto R   Sasso Rosa Cinzia RC   Sabbà Carlo C   Palasciano Giuseppe G   Moschetta Antonio A  

Biochimica et biophysica acta 20160712 11

Extra virgin olive oil (EVOO) consumption has been associated with reduced cardiovascular risk but molecular mechanisms underlying its beneficial effects are not fully understood. Here we aimed to identify genes and miRNAs expression changes mediated by acute high- and low-polyphenols EVOO intake. Pre- and post-challenge gene and miRNAs expression analysis was performed on the peripheral blood mononuclear cells (PBMCs) of 12 healthy subjects and 12 patients with metabolic syndrome (MS) by using  ...[more]

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