Transcription profile of aging and cognitive-related genes in the medial prefrontal cortex and hippocampal region CA1

ABSTRACT: This study focused on transcription in the medial PFC (mPFC) as a function of age and cognition. Young and aged F344 rats were characterized on tasks, attentional set shift and spatial memory, which depend on the mPFC and hippocampus, respectively. Differences in transcription associated with age and cognitive function were examined using RNA sequencing to construct transcriptomic profiles for the mPFC, white matter, and region CA1 of the hippocampus. The results indicate regional differences in vulnerability to aging associated with increased expression of immune and defense response genes and a decline in synaptic and neural activity genes. Importantly, we provide evidence for region specific transcription related to behavior. In particular, expression of transcriptional regulators and n

ORGANISM(S): Rattus norvegicus

SUBMITTER: Thomas Foster 

PROVIDER: E-GEOD-75772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress