Transcription profiling by array of human tumor cells with stem-like properties isolated from pediatric brain tumors

ABSTRACT: Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pediatric brain tumors and are of clinical relevance remains to be determined.
Methodology/Principal findings
Tumor cells with self-renewal properties were isolated with cell biology techniques from a majority of 55 pediatric brain tumors samples, regardless of their histopathologies and grades of malignancy (57% of embryonal tumors, 57% of low-grade gliomas and neuro-glial tumors, 70% of ependymomas, 91% of high-grade gliomas). The vast majority (10/12) of high-grade glioma-derived oncosph

ORGANISM(S): Homo sapiens

DISEASE(S): Astrocytoma III

SUBMITTER: Marie-Pierre Junier 

PROVIDER: E-MEXP-2910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress