PD1 completely suppresses the transcriptional response induced by the T cell receptor

ABSTRACT: Functional impairment of the immune response to chronic viral infections and malignancies is characterised by exhausted T cells, which do not respond to antigen. The cell surface receptor PD1 has been implicated in the maintenance of T cell exhaustion and is an attractive target for immunomodulatory approaches to the treatment of such conditions. However, the mechanisms by which PD1 signalling causes exhaustion and the exact response of T cells to PD1 activation are not clear although it has been suggested that PD1 up regulates a number of anti-proliferative factors. Here we perform cytokine and transcriptional profiling of uninfected primary human T cells to characterise these events. We find that PD1 completely prevents cytokine and transcrip- tional changes induced by CD3/28 stimulation

ORGANISM(S): Homo sapiens

SUBMITTER: Ben Sidders 

PROVIDER: E-MEXP-3410 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress