Unknown,Transcriptomics,Genomics,Proteomics

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5Aza and TSA treatment of MCF7 cells (BS-seq)


ABSTRACT: The goal of this study is to identify the DNA methylation changes caused by exposure of to the DNMT inhibitor 5-aza-2’-deoxycytidine (5Aza) and HDAC inhibitor Trichostatin A (TSA). We performed whole-genome bisulfite sequencing of the drug-treated MCF7 breast cancer cell lines and compare their DNA methylation profile with the untreated MCF7 (see E-MTAB-2014). While MCF7 treated with both drugs experienced global loss of DNA methylation, the 5Aza induced stronger demethylation than TSA.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: I-Hsuan Lin 

PROVIDER: E-MTAB-3785 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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