Single cell RNA-seq and VDJ-seq of B cells from sheep red blood cells-primed WT and Stch cKO mice

ABSTRACT: Once activated, B cells produce the antibodies needed to fight against infection. B cells are necessary for adaptive or specific immunity, which focuses on the destruction of foreign invaders that have gotten past the bodies initial defenses. Heat shock protein family is a group of highly conserved molecular chaperones with important functions in protein folding such as antibody and in signal transduction. Stch (Heat shock 70 kDa protein 13) is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins. To explore the role of Stch in B-cell activation and antibody production, we evaluated the transcriptional events and the role of stch pathway on the activation and an

INSTRUMENT(S): Illumina HiSeq 4000, 10x Genomics

ORGANISM(S): Mus musculus

SUBMITTER: Renxi Wang 

PROVIDER: E-MTAB-8280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress