Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human cell lines treated with cytochalasin D and nocodazole with the aim of characterising tetraploid clones


ABSTRACT: During the oncogenic process, tetraploidy is a candidate intermediate stage leading from diploidy to aneuploidy. The aim of our experiment was to establish tetraploid clones and to characterize their transcriptome.

ORGANISM(S): Homo sapiens

SUBMITTER: Nazanine Modjtahedi 

PROVIDER: E-TABM-70 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Tetraploidy can result in cancer-associated aneuploidy. As shown here, freshly generated tetraploid cells arising due to mitotic slippage or failed cytokinesis are prone to undergo Bax-dependent mitochondrial membrane permeabilization and subsequent apoptosis. Knockout of Bax or overexpression of Bcl-2 facilitated the survival of tetraploid cells at least as efficiently as the p53 or p21 knockout. When tetraploid cells were derived from diploid p53 and Bax-proficient precursors, such cells exhib  ...[more]

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