Transcription profiling of human CD34+ cells from familial platelet disorder

ABSTRACT: Characterize the genes deregulated in CD34 positive cells from peripheral blood of FPD/AML patients harbouring two different RUNX1 mutations. RUNX1 (also called AML1), a DNA-binding subunit of the CBF transcription factor family, is a master regulatory gene in hematopoiesis and acts as a tumour suppressor. Heterozygous germ line alterations in RUNX1 lead to a familial platelet disorder with a propensity to develop acute myeloid leukemia (FPD/AML). Although RUNX1 abnormalities per se are not sufficient to induce full-blown leukemia in FPD, this pathology represents a valuable model to understand how RUNX1 germ line mutations predispose to acquisition of additional genetic changes leading to leukemia transformation. To investigate how RUNX1 may predispose to leukemia, we performed a comparat

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Hugues RIPOCHE 

PROVIDER: E-TABM-792 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress