Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study.

ABSTRACT: Tryptophan is an essential amino acid. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the tryptophan-kynurenine pathway, is positively associated with cardiac events, and may be relevant to cancer. We used Mendelian Randomization to obtain unconfounded estimates of the association of IDO1 with ischemic heart disease (IHD), ischemic stroke and their risk factors, all-cancer, cancer of the prostate, lung and bronchus, and breast. We obtained genetic instruments independently and strongly (p-value?

SUBMITTER: Li M 

PROVIDER: S-EPMC6560130 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature