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Aneuploidy and proteotoxic stress in cancer.

ABSTRACT: Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our findings implicate HSF1 as a key factor in mitigating the effects of aneuploidy.

SUBMITTER: Donnelly N

PROVIDER: S-EPMC4904904 | biostudies-other | 2015 Apr-Jun

REPOSITORIES: biostudies-other

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