Ontology highlight
ABSTRACT: The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering new therapeutic targets and biomarkers. We present a dataset consisting of DNA sequencing from 91 CLL samples (with matched germline controls). Samples were collected from patients displaying a wide range of characteristics representing the broad clinical spectrum of CLL. Understanding the mutational landscape of CLL provides a starting point for systematic analyses to address fundamental questions in CLL, including how mutated genes alter cellular networks and phenotypes, and thereby contribute to disease heterogeneity.
OTHER RELATED OMICS DATASETS IN: PRJNA158601
PROVIDER: phs000435.v1.p1 | EGA |
REPOSITORIES: EGA
Wang Lili L Lawrence Michael S MS Wan Youzhong Y Stojanov Petar P Sougnez Carrie C Stevenson Kristen K Werner Lillian L Sivachenko Andrey A DeLuca David S DS Zhang Li L Zhang Wandi W Vartanov Alexander R AR Fernandes Stacey M SM Goldstein Natalie R NR Folco Eric G EG Cibulskis Kristian K Tesar Bethany B Sievers Quinlan L QL Shefler Erica E Gabriel Stacey S Hacohen Nir N Reed Robin R Meyerson Matthew M Golub Todd R TR Lander Eric S ES Neuberg Donna D Brown Jennifer R JR Getz Gad G Wu Catherine J CJ
The New England journal of medicine 20111212 26
<h4>Background</h4>The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood.<h4>Methods</h4>We obtained DNA samples from leukemia cells in 91 patients with chronic lymphocytic leukemia and performed massively parallel sequencing of 88 whole exomes and whole genomes, together with sequencing of matched germline DNA, to characterize the spectrum of somatic mutations in this disease.<h4>Results</h4>Nine ...[more]