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GEP signatures in tumors from women with high grade early breast cancer [PrimitiveTumor].

ABSTRACT: Several molecular signatures are able to predict the activity of adjuvant chemotherapy in breast cancer patients. However, no molecular data are already available to detect microenvironment molecular signature that can identify patients who are good candidates for treatment with immune checkpoint inhibitors (ICIs). For this reason, in a series of women with operable high grade breast cancer (HGBC), we tried to combine the ECM3 and IFN molecular signatures reflecting different aspects of tumor microenvironment that can better draw the picture of the tumor microenvironment in which the immune cells are in close contact with extracellular matrix. Grade 3 primary tumors

ORGANISM(S): Homo sapiens

PROVIDER: GSE147471 | GEO | 2020/12/23

REPOSITORIES: GEO

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GEP signatures in tumors from women with high grade early breast cancer

Project description:Several molecular signatures are able to predict the activity of adjuvant chemotherapy in breast cancer patients. However, no molecular data are already available to detect microenvironment molecular signature that can identify patients who are good candidates for treatment with immune checkpoint inhibitors (ICIs). For this reason, in a series of women with operable high grade breast cancer (HGBC), we tried to combine the ECM3 and IFN molecular signatures reflecting different aspects of tumor microenvironment that can better draw the picture of the tumor microenvironment in which the immune cells are in close contact with extracellular matrix. Subgroup of G3 tumors extracted from the ECTO1 study (Gianni L. et al, JCO 2009)

2020-12-23 | GSE147472 | GEO

GEP signatures in tumors from women with high grade early breast cancer

Project description:GEP signatures in tumors from women with high grade early breast cancer

| PRJNA614941 | ENA

GEP signatures in tumors from women with high grade early breast cancer [PrimitiveTumor].

Project description:GEP signatures in tumors from women with high grade early breast cancer [PrimitiveTumor].

| PRJNA614942 | ENA

GEP signatures of primary breast cells radiation treated.

Project description:Breast cancer (BC) recovery has considerably increased thanks to the advances achieved from research in this field. However, despite the important results obtained, BC remains a complex multifactorial disease with distinct subtypes associated with different outcomes.So, many efforts from radiobiological research are needed to help clinicians in understanding molecular features of a specific tumor subtype, in order to better define the most successful treatment plan, including the choice of the best Radiation Teraphy (RT) modality and schedule in clinical practice. The aim of the present study was to analyze the GEPs in primary breast cancer cells following irradiation with doses of 9 Gy and 23 Gy electron beam delivered by IOERT treatment, in order to define gene signatures of response to high doses of IR.

2021-02-19 | GSE110933 | GEO

GEP signatures of primary breast cells radiation treated.

Project description:GEP signatures of primary breast cells radiation treated.

| PRJNA435496 | ENA

Proteomic study on human breast cancer cells in response to different folate levels

Project description:The consequence of a supra-physiological folate tumour microenvironment in promoting metastasis potential of human breast cancers remains unexplored. This study examined the molecular mechanism by which clinically aberrant folate levels may promote mitochondria and glycolytic stress-associated proteomic signatures to promote metastasis potential of human MCF-7 breast cancer cells.

2022-11-21 | PXD011046 | Pride

LobSig a prognostic gene expression signature for invasive lobular carcinoma -Gene Expression Profiling

Project description:Analysis of invasive lobular carcinoma (ILC) at gene expression level. Samples are annotated with breast cancer specific survival (BCSS) and tumour grade. Results are part of a larger study about molecular signatures that are associated with distinct clinical outcomes in ILC.

2019-06-17 | GSE98528 | GEO

Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

Project description:Analysis of miRNA expression in grade 3 luminal, sporadic and BRCA1 associated basal-like breast cancers 44 primary grade III breast cancer (11 BRCA1 basal, 16 sporadic basal, 17 luminal) and 13 normal breast FFPE (formalin fixed, paraffin embedded) specimens, plus 7 controls and 5 cell lines were analysed. The aim of the study was to derive grade-specific miRNA signatures for sporadic and BRCA1 basal-like breast cancers, and to ascertain an immunohistochemical profile regulated by BRCA1 specific miRNAs for potential diagnostic uses.

2014-09-16 | E-GEOD-61438 | biostudies-arrayexpress

T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model

Project description:Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs) which are more severe when ICIs are used in combination. A mouse model was developed to elucidate the molecular mechanisms of immune-related hepatitis, one of the common irAEs associated with ICIs. Molecular profiling by single cell RNA sequencing was performed on Pdcd1-/- mice treated with anti-CTLA4 and/or the IDO1 inhibitor epacadostat or a 4-1BB agonistic antibody. ICI combination-induced hepatitis and 4-1BB agonist-mediated hepatitis share similar features yet maintain distinct immune signatures. Both were characterized by an expansion of activated T cells. Single-cell transcriptomics revealed that the hepatitis induced by combination ICIs is associated with a robust immune activation signature in all subtypes of T cells and T helper 1 skewing. Expression profiling revealed a central role for IFNγ and liver monocyte-derived macrophages in promoting a pro-inflammatory T-cell response to ICI combination and 4-1BB agonism.

2022-11-14 | GSE217917 | GEO

T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model II

2022-11-16 | GSE218139 | GEO

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