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Integrative functional transcriptomic analyses implicate shared molecular circuits in sensorineural hearing loss

ABSTRACT: Aging, noise exposure, and ototoxic drugs represent the three main causes of SNHL, leading to substantial similarities in pathophysiological characteristics of cochlear degeneration. Although the common molecular mechanisms are widely assumed to underlie these similarities, its validity lacks systematic examination. To address this question, we generated three SNHL mouse models from aging, noise exposure, and cisplatin ototoxicity and constructed gene coexpression networks for the cochlear transcriptome data across different hearing-damaged stages.

ORGANISM(S): Mus musculus

PROVIDER: GSE196870 | GEO | 2022/02/16

REPOSITORIES: GEO

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