α-Synuclein promotes H4R3me2s through interacting with BAF-PRMT5 complex

ABSTRACT: We conducted a screening for nuclear proteins which interact with α-synuclein by mass-spectrometry. As a result, we found that α-synuclein interact with BAF complex. Furthermore, overexpressed α-synuclein increased global H4R3me2s by promoting interaction between BAF complex and PRMT5 in cultered cells. In this study, we explored the influence of overexpressed α-synuclein on H4R3me2s by ChIP-seq using anti-H4R3me2s antibody.

ORGANISM(S): Homo sapiens

PROVIDER: GSE228331 | GEO | 2023/11/23

REPOSITORIES: GEO