Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS - Mouse Mesenteric Lymph Node Metabolites

ABSTRACT: Small molecules extracted from mouse mesenteric lymph nodes.

INSTRUMENT(S): Q-Exactive

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Gabriel Haddad

PROVIDER: MSV000080181 | GNPS |

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Similar Datasets

Metabolomic profiling of twenty metabolites from human tissues in six studies

Project description:Twenty metabolites across 6 studies, with 6 groups of experimental subjects

2008-06-21 | E-TABM-290 | biostudies-arrayexpress

Comparison between Nestin+ and Nestin- Ptch1 deficient GNPs

Project description:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here we report that Nestin binds the hedgehog pathway transcription factor Gli3 to mediate the development of medulloblastomas of the hedgehog subtype. In a mouse model system, Nestin levels increased progressively during medulloblastoma formation resulting in enhanced tumor growth. Conversely, loss of Nestin dramatically inhibited proliferation and promoted differentiation. Mechanistic investigations revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. Nestin binding to Gli3 blocked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability to negatively regulate the hedgehog pathway. Our findings show how Nestin drives hedgehog pathway-driven cancers and uncover in Gli3 a therapeutic target to treat these malignancies. Nestin+ and Nestin- GNPs (granule neuron precursors) were purified from Nestin-CFP/Math1-Cre/Ptch1-loxp cerebella at postnatal day 4 by FACs, and total RNA from these two cell populations were extracted, and then labeled and hybridized to Affymetrix Mouse Genome 430 2.0 arrays.

2016-08-09 | E-GEOD-84392 | biostudies-arrayexpress

Small RNA sequencing from transgenic Arabidopsis 35S:GUS (lines 6b4 and L1) and 35S:SUG (line SUG6)

Project description:Transgene loci were transfered in different Arabidopsis thaliana mutant backgrounds by crossing. Small RNA molecules were extracted and sequenced to survey the influence of mutations on transgene small RNA biogenesis.

2019-12-05 | GSE141442 | GEO

Comparison between Nestin+ and Nestin- Ptch1 deficient GNPs

2016-08-09 | GSE84392 | GEO

Plasma DNA end analysis (mouse)

Project description:Plasma DNA end analysis (mouse)

| EGAS00001006700 | EGA

Signatures of protein and small RNA cargoes in extracellular vesicles of mouse testis

Project description:We report the small RNA transcriptome of testicular extracellular vesicles in mouse testis. We established a testis dissociation protocol to isolate testicular extracellular vesicles. After treatment with proteinase K and RNase A, the RNA inside the extracellular vesicles was extracted and sequenced by small RNA-seq.

2022-01-31 | GSE158402 | GEO

RNA sequencing of mouse basal-derived prostate organoids treated with vehicle, UK5099, Butyrate, or UK5099+Butyrate

Project description:The goal of this study was to perform transcriptomics on vehicle-, UK5099-, Butyrate-, and UK5099+Butyrate-treated mouse prostate organoids. We used FACS to isolate basal cells from C57BL/6 mouse prostates and treated with small molecules for one week before harvesting for RNA-sequencing.

2023-09-01 | GSE236573 | GEO

Identify molecules regulated by glucosylceramide synthase in mouse osteoblasts.

Project description:Identify molecules regulated by glucosylceramide synthase in mouse osteoblasts.

| PRJNA729440 | ENA

Jagged ends of plasma DNA (mouse)

Project description:Jagged ends of plasma DNA (mouse)

| EGAS00001005563 | EGA

Induction of mouse totipotent stem cells by a defined chemical cocktail [RRBS]

Project description:We demonstrate induction and long-term maintenance of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs) by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. These cells, which we designated as ciTotiSCs (chemically induced totipotent stem cells), resembled mouse totipotent 2C-embryo stage cells at both transcriptome and epigenome level.

2022-05-25 | GSE185004 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data