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Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway

ABSTRACT: The purpose of this study is to investigate the therapeutic effect of MSC-derived apoVs treatment on NIHL and the potential mechanism of resisting oxidative stress damage in hair cells, as well as the distribution of apoptotic vesicles in the inner ear. The study provided a new direction for the treatment of noise-induced hearing loss and inner ear delivery.

ORGANISM(S): Homo Sapiens

SUBMITTER: Haidi Yang

PROVIDER: PXD040989 | iProX | Mon Mar 20 00:00:00 GMT 2023

REPOSITORIES: iProX

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Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.

Huang Xiaotong X Kou Xiaoxing X Zhan Ting T Wei Guokun G He Feinan F Mao Xueli X Yang Haidi H

Stem cell research & therapy 20230415 1

<h4>Background</h4>Mesenchymal stem cell (MSC) transplantation is a promising therapeutic approach for noise-induced hearing loss (NIHL). As the indispensable role of apoptosis in MSC transplantation was raised, the benefits of MSC-derived apoptotic vesicles (apoVs) in several disease models have been proved. However, whether apoVs benefit in NIHL have not been studied yet.<h4>Methods</h4>Female CBA/J mice and HEI-OC1 cells were used in this study. Flow cytometry, nanoparticle tracking analysis ...[more]

PMID: 37061707

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