Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Cell Culture, Macrophage
SUBMITTER: Maxence Wisztorski
LAB HEAD: Michel Salzet
PROVIDER: PXD004444 | Pride | 2018-03-19
REPOSITORIES: Pride
Molecular & cellular proteomics : MCP 20180312 6
High grade gliomas are the most common brain tumors in adult. These tumors are characterized by a high infiltration in microglial cells and macrophages. The immunosuppressive tumor environment is known to orient immune cells toward a pro-tumoral and anti-inflammatory phenotype. Therefore, the current challenge for cancer therapy is to find a way to reorient macrophages toward an antitumoral phenotype. Previously, we demonstrated that macrophages secreted antitumoral factors when they were invali ...[more]