Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Nicolas Nalpas
LAB HEAD: Koraljka Husnjak
PROVIDER: PXD005878 | Pride | 2017-03-21
REPOSITORIES: Pride
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Nature methods 20170320 5
Ubiquitination controls a plethora of cellular processes. Modifications by linear polyubiquitin have so far been linked with acquired and innate immunity, lymphocyte development and genotoxic stress response. Until now, a single E3 ligase complex (LUBAC), one specific deubiquitinase (OTULIN) and a very few linear polyubiquitinated substrates have been identified. Current methods for studying lysine-based polyubiquitination are not suitable for the detection of linear polyubiquitin-modified prote ...[more]