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CLL exosomes - S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression

ABSTRACT: CLL exosomes purification during disease evolution from different patients

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Blood Plasma

DISEASE(S): Acute Leukemia

SUBMITTER: Pablo Oppezzo

LAB HEAD: Pablo Oppezzo

PROVIDER: PXD005941 | Pride | 2017-06-19

REPOSITORIES: Pride

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S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression.

Prieto Daniel D Sotelo Natalia N Seija Noé N Sernbo Sandra S Abreu Cecilia C Durán Rosario R Gil Magdalena M Sicco Estefanía E Irigoin Victoria V Oliver Carolina C Landoni Ana Inés AI Gabus Raúl R Dighiero Guillermo G Oppezzo Pablo P

Blood 20170608 6

Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clonal B lymphocytes, resulting from a complex balance between cell proliferation and apoptotic death. Continuous crosstalk between cancer cells and local/distant host environment is required for effective tumor growth. Among the main actors of this dynamic interplay between tumoral cells and their microenvironment are the nano-sized vesicles called exosomes. Emerging evidence indicates that secretion, co ...[more]

PMID: 28596424

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