Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Cowpox Virus Cowpox Virus (cpv)
TISSUE(S): Permanent Cell Line Cell
SUBMITTER: Marica Grossegesse
LAB HEAD: Andreas Nitsche
PROVIDER: PXD006426 | Pride | 2018-02-07
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
CPXVBrightonRed_ubi_names.fasta | Fasta | |||
CPXVHumBer_ubi_names.fasta | Fasta | |||
CPXVHumGri_ubi_names.fasta | Fasta | |||
CPXVRatHei_ubi_names.fasta | Fasta | |||
CPXVRatKre_ubi_names.fasta | Fasta |
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Scientific reports 20180129 1
The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ubiquitin-proteasome system attractive antiviral targets. We show that proteasome inhibition impairs CPXV replication by prevention of uncoating, suggesting that uncoating is mediated by proteasomal degradation of viral core proteins. Although Orthop ...[more]