Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: David Vaux
LAB HEAD: David J Vaux
PROVIDER: PXD006459 | Pride | 2017-05-30
REPOSITORIES: Pride
Boubriak Ivan I II Malhas Ashraf N AN Drozdz Marek M MM Pytowski Lior L Vaux David J DJ
PloS one 20170524 5
The nuclear lamina can bind and sequester transcription factors (TFs), a function lost if the lamina is abnormal, with missing or mutant lamin proteins. We now show that TF sequestration is not all-or-nothing, but a dynamic physiological response to external signals. We show that the binding of the ubiquitous TF, Oct-1, to lamin B1 was reversed under conditions of cellular stress caused, inter alia, by the chemical methylating agent methylmethanesulfonate (MMS). A search for lamin B1 post-transl ...[more]