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Proteins present in tears from control, MCI and Alzheimer disease patients

ABSTRACT: we investigated tear fluid as a novel source of disease-specific protein biomarkers for Alzheimer disease (AD) development using samples from patients suffering from mild cognitive impairment (MCI) and AD. Tear protein content was evaluated via liquid chromatography–mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Secretion Of Lacrimal Gland, Tear

DISEASE(S): Alzheimer's Disease

SUBMITTER: Felix Hernandez

LAB HEAD: Felix Hernandez

PROVIDER: PXD014475 | Pride | 2019-11-04

REPOSITORIES: Pride

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Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease.

Kenny Aidan A Jiménez-Mateos Eva M EM Zea-Sevilla María Ascensión MA Rábano Alberto A Gili-Manzanaro Pablo P Prehn Jochen H M JHM Henshall David C DC Ávila Jesús J Engel Tobias T Hernández Félix F

Scientific reports 20191028 1

Alzheimer's disease (AD) is characterized by a progressive loss of neurons and cognitive functions. Therefore, early diagnosis of AD is critical. The development of practical and non-invasive diagnostic tests for AD remains, however, an unmet need. In the present proof-of-concept study we investigated tear fluid as a novel source of disease-specific protein and microRNA-based biomarkers for AD development using samples from patients with mild cognitive impairment (MCI) and AD. Tear protein conte ...[more]

PMID: 31659197

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