Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Prahlad Raninga
LAB HEAD: Kum Kum Khanna
PROVIDER: PXD015141 | Pride | 2020-05-27
REPOSITORIES: Pride
Raninga Prahlad V PV Lee Andy A Sinha Debottam D Dong Lan-Feng LF Datta Keshava K KK Lu Xue X Kalita-de Croft Priyakshi P Dutt Mriga M Hill Michelle M Pouliot Normand N Gowda Harsha H Kalimutho Murugan M Neuzil Jiri J Khanna Kum Kum KK
Theranostics 20200406 12
<b>Purpose</b>: Lacking effective targeted therapies, triple-negative breast cancer (TNBCs) is highly aggressive and metastatic disease, and remains clinically challenging breast cancer subtype to treat. Despite the survival dependency on the proteasome pathway genes, FDA-approved proteasome inhibitors induced minimal clinical response in breast cancer patients due to weak proteasome inhibition. Hence, developing effective targeted therapy using potent proteasome inhibitor is required. <b>Method ...[more]