Proteomics

Dataset Information

0

Purification of ubiquitylated proteins from HCT116 cells


ABSTRACT: By hyperosmotic stimuli, a slight increase in the level of ubiquitylated proteins was observed. So we tried to identify the di-Gly peptides.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Hikaru Tsuchiya  

LAB HEAD: Yasushi Saeki

PROVIDER: PXD016369 | Pride | 2020-02-18

REPOSITORIES: Pride

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The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins<sup>1,2</sup>. A number of ubiquitin-related molecules have recently been found to be involved in the regulation of biomolecular condensates or membraneless organelles, which arise by liquid-liquid phase separation of specific biomolecules, including stress granules, nuclear speckles and autophagosomes<sup>3-8</sup>, but it remains unclear whether the proteas  ...[more]

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