Proteomic analysis of ∆4-CYB complex III mutant cybrids
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ABSTRACT: The mitochondrial respiratory chain (MRC) enzymes associate in supercomplexes (SC). This structural interdependency may explain why defects in a single component often produce combined enzyme deficiencies in patients. A point in case is the alleged destabilization of complex I in the absence of complex III. To clarify the structural and functional relationships between complexes, we have used comprehensive proteomic, functional and biogenetical approaches to analyze a MT-CYB-deficient human cell line.
INSTRUMENT(S): LTQ Orbitrap, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Erika Fernandez-Vizarra
LAB HEAD: Massimo Zeviani
PROVIDER: PXD016521 | Pride | 2020-01-07
REPOSITORIES: Pride
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