Proteomics

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Proteomic analysis of ∆4-CYB complex III mutant cybrids


ABSTRACT: The mitochondrial respiratory chain (MRC) enzymes associate in supercomplexes (SC). This structural interdependency may explain why defects in a single component often produce combined enzyme deficiencies in patients. A point in case is the alleged destabilization of complex I in the absence of complex III. To clarify the structural and functional relationships between complexes, we have used comprehensive proteomic, functional and biogenetical approaches to analyze a MT-CYB-deficient human cell line.

INSTRUMENT(S): LTQ Orbitrap, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Erika Fernandez-Vizarra  

LAB HEAD: Massimo Zeviani

PROVIDER: PXD016521 | Pride | 2020-01-07

REPOSITORIES: Pride

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