Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Lung Cancer
SUBMITTER: Elena Ossipova
LAB HEAD: Meike J. Saul
PROVIDER: PXD016803 | Pride | 2020-03-02
REPOSITORIES: Pride
Emmerich Anne C AC Wellstein Julia J Ossipova Elena E Baumann Isabell I Lengqvist Johan J Kultima Kim K Jakobsson Per-Johan PJ Steinhilber Dieter D Saul Meike J MJ
Frontiers in pharmacology 20200313
MicroRNAs (miRs) are one of the most important post-transcriptional repressors of gene expression. However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a key enzyme in the prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) biosynthesis, by acting as decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1) in human lung cancer. miR-574-5p exhibits oncogenic properties and promotes lung tumor growth <i>in vivo</ ...[more]